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2022-06-23

Ectin Research AB visar positiva preliminära data avseende ytterligare tillämpningsområde av MFA-370

Ectin Research AB (”Ectin” eller ”Bolaget) meddelar idag att Bolagets uppdragsforskning tillsammans med Sahlgrenska akademin, Göteborgs Universitet, visar positiva preliminära data. Syftet var att i human experimentella modeller undersöka om Ectins kombinationsterapi MFA-370 utöver behandling av metastaserad urotelial blåscancer också skulle kunna användas vid behandling av ytterligare cancerindikationer. Den aktuella studien utfördes i preklinisk modell för peritoneal carcinomatos dvs cancer där spridning skett till bukhinnan.

Ectin har tidigare i prekliniska studier visat att MFA-370 har anti-proliferativ (tillväxthämmande) effekt samt ger upphov till specifik cancercell död när prövad mot uroteliala blåscancerceller samt bröst-, kolon- och prostatacancerceller. Tillsammans med Sahlgrenska akademin, Göteborgs Universitet, har Ectin nu genomfört prekliniska studier för att undersöka huruvida bolagets cancerterapi MFA-370 potentiellt även kan användas för behandling av peritoneal carcinomatos (PC).

Vid avancerade stadier av kolorektalcancer (cancer i tjock- och ändtarm) kan tumörceller spridas till bukhinnan och orsaka PC. När tumörceller fått fäste och spridit sig vidare in i bukhinnan är detta oftast förknippat med en dyster prognos. Den idag tillgängliga behandlingen lämpar sig inte för alla patienter då den är avancerad, tidskrävande och förknippad med många biverkningar. Behandlingseffekten är dessutom begränsad. Behovet av alternativa behandlingar är därmed stort. Preliminära data från experimentella modeller visar nu att MFA-370 kan minska vidhäftning av tumörceller till bukhinnans yta. Detta kan vara ett steg i rätt riktning mot en ny uppföljande indikation för MFA-370. Fortsatta studier planeras nu för att utreda frågeställningen vidare.

Ectin visar positiva preliminära data avseende ytterligare tillämpningsområde av MFA-370

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AstraZeneca BioVentureHub
Pepparedsleden 1
SE-431 83 Mölndal
Sweden

About Ectin Research AB

Ectin Research AB pharmaceutical company is developing a novel treatment that aims to eliminate cancer tumors. Its drug candidate MFA-370 will first be trialled for the treatment of metastatic urothelial bladder cancer. MFA-370 consists of two existing drugs that have already undergone large-scale clinical trials and are currently widely used in other indications. In preclinical studies MFA-370 has achieved successful results for the treatment of metastatic urothelial bladder cancer, and has also shown promising potential in other cancers such as breast, colorectal and prostate cancer cells.

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